PANZYGA® (Immune Globulin Intravenous (Human)-ifas, 10% solution)

CIDP
dosing and
administration

CIDP
infusion rate chart

CIDP
infusion rate calculator

Tab Number 4

Tab Number 5

The first and only IVIg with 2 FDA-approved maintenance dosing options for CIDP in adults¹

In the CIDP study, a loading dose of 2 g/kg of PANZYGA was given followed by 7 maintenance infusions every 3 weeks over a period of 6 months¹
The initial infusion rate should be maintained for 30 minutes, and if tolerated, the infusion rate may be gradually increased every 15 to 30 minutes to a maximum of 12 mg/kg/min (0.12 mL/kg/min) as tolerated¹

In the CIDP study, a loading dose of 2 g/kg of PANZYGA was given followed by 7 maintenance infusions every 3 weeks over a period of 6 months¹
The initial infusion rate should be maintained for 30 minutes, and if tolerated, the infusion rate may be gradually increased every 15 to 30 minutes to a maximum of 12 mg/kg/min (0.12 mL/kg/min) as tolerated¹

Example ramp-up schedule for an adult patient with CIDP

PANZYGA should be started at 1 mg/kg/min and continued at the infusion rates stated here, if tolerated¹

The example shown above illustrates a ramp-up schedule for an 80-kg patient using rates of 1, 2, 4, 8, and 12 mg/kg/min

For patients at risk of renal dysfunction or thromboembolic events, administer PANZYGA at the minimum infusion rate practicable. Do not exceed 3.3 mg/kg/min (0.033 mL/kg/min). Discontinue if renal function deteriorates¹

Reference:

Panzyga. Prescribing information. Octapharma USA Inc.; 2021.

The PANZYGA infusion rate chart below will help you calculate the appropriate infusion rate for an adult patient with CIDP

Loading Dose: 2 g/kg (20 mL/kg), divided into 2 daily doses of 1 g/kg (10 mL/kg) given on 2 consecutive days¹
Maintenance Dose: 1 g/kg or 2 g/kg (10-20 mL/kg) every 3 weeks divided in 2 doses given over 2 consecutive days¹
The initial infusion rate should be maintained for 30 minutes. Following the initial infusion, and if tolerated, the infusion rate may be gradually increased every 15 to 30 minutes, as tolerated, to the maximum infusion rate of 12 mg/kg/min (0.12 mL/kg/min)¹

Download the PANZYGA CIDP Infusion Rate Chart

Reference:

Panzyga. Prescribing information. Octapharma USA Inc.; 2021.

Step 1: Choose an indication

With this calculator, you can determine the:

infusion ramp-up rate to program into an IV infusion pump
estimated time to complete the infusion

Choose an indication:

Step 2: Enter the patient’s body weight and PANZYGA dose for this infusion

Adult patient with CIDP

One field from each section below is required.

Enter patient’s body weight

Enter value *

AND

Enter patient’s PANZYGA dose for this infusion

Enter value *

Calculated answer: Recommended ramp-up infusion rates

Adult patient with CIDP

Based on patient’s body weight of {{weight}} and a dose of {{dose}} of PANZYGA, see below for recommended ramp-up infusion rates.

First 30 minutes

0.01 mL/kg/min
(1 mg/kg/min)

mL/hr

Next 15-30 minutes

(if previous is tolerated)

0.02 mL/kg/min
(2 mg/kg/min)

mL/hr

Next 15-30 minutes

(if previous is tolerated)

0.04 mL/kg/min
(4 mg/kg/min)

mL/hr

Next 15-30 minutes

(if previous is tolerated)

0.08 mL/kg/min
(8 mg/kg/min)

mL/hr

Maximum Infusion Rate

(if previous is tolerated)

0.12 mL/kg/min
(12 mg/kg/min)

mL/hr

Estimated time to infuse {{dose}} is between {{minInfusionTime}} - {{maxInfusionTime}}

(if the rates above are tolerated by the patient)

Step 2: Enter patient's body weight and PANZYGA dose for this infusion

Patient 2 years or older with PI

One field from each section below is required.

Enter patient’s body weight

Enter value *

AND

Enter patient’s PANZYGA dose for this infusion

Enter value *

Calculated answer: Recommended ramp-up infusion rates

Patient 2 years or older with PI

Based on patient’s body weight of {{weight}} and a dose of {{dose}} of PANZYGA, see below for recommended ramp-up infusion rates.

First 30 minutes

0.01 mL/kg/min
(1 mg/kg/min)

mL/hr

Next 15-30 minutes

(if previous is tolerated)

0.04 mL/kg/min
(4 mg/kg/min)

mL/hr

Next 15-30 minutes

(if previous is tolerated)

0.08 mL/kg/min
(8 mg/kg/min)

mL/hr

Maximum Infusion Rate

(if previous is tolerated)

0.14 mL/kg/min
(14 mg/kg/min)

mL/hr

Estimated time to infuse {{dose}} is between {{minInfusionTime}} - {{maxInfusionTime}}

(if the rates above are tolerated by the patient)

Step 2: Enter the patient’s body weight and PANZYGA dose for this infusion

Adult patient with cITP

One field from each section below is required.

Enter patient’s body weight

Enter value *

AND

Enter patient’s PANZYGA dose for this infusion

Enter value *

Calculated answer: Recommended ramp-up infusion rates

Adult patient with cITP

Based on patient’s body weight of {{weight}} and a dose of {{dose}} of PANZYGA, see below for recommended ramp-up infusion rates.

First 30 minutes

0.01 mL/kg/min
(1 mg/kg/min)

mL/hr

Next 15-30 minutes

(if previous is tolerated)

0.04 mL/kg/min
(4 mg/kg/min)

mL/hr

Maximum Infusion Rate

(if previous is tolerated)

0.08 mL/kg/min
(8 mg/kg/min)

mL/hr

Estimated time to infuse {{dose}} is between {{minInfusionTime}} - {{maxInfusionTime}}

(if the rates above are tolerated by the patient)